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'Plant and Algal Natural Products' laboratory


Gábor Vasas associate professor
Sándor Gonda senior lecturer

Minh Nguyen Nhat PhD student
Péter Parizsa PhD student
Milán Riba PhD student
Zsolt Szűcs PhD student

Erzsébet Barna research assistant

 

Main fields of research, main activities


The natural products from higher plants, algae and endophytic fungi are of chief research interest of this laboratory. The main goals of this research is to study the effects, biosynthesis, in vitro production and ecology of these compounds, as well as to optimize methods for their purification and develop analytical methods that can be used for their quantification.
The more important, characterized organisms include toxic algal strains (Microcystis sp., Aphanisomenon sp., Cylindrospermopsis sp., among others), carotenoid-producing non-toxic algae (Dunaliella salina, Nostoc sp.), medicinal plants (e.g. Plantago lanceolata), edible plants and spices (Crocus sativus, Armoracia rusticana), and plant-associated fungi, endophytes.
The main compound gropus of interest are peptide and other cyanotoxins, carotenoids from algae, phenylethanoid glycosides and other phenoloids from higher plants.
The analytical methods developed and used for characterization of natural product mixtures include capillary electrophoresis (CE), preparative methods, and hyphenated techniques (GC-MS, LC-MSn). For the data processing, the „omics” approach is used with increasing intensity.


Research topics


    Analysis of toxin content of cyanobacterial and algal mass productions in Hungarian water bodies, and examination of toxin production in isolated algal and cyanobacterial strains (OTKA K 81370, principal investigator: Gábor Vasas)
    Study of endophyte-plant interactions with metabolomic techniques in horseradish (OTKA PD 112374, principal investigator: Gonda Sándor)
    Examination of bioactive natural products (glucosinolates and isothiocyanates) and metabolite biosynthesis genes of horseradish (Armoracia rusticana) and its relatives
    Study of bioactive natural products of saffron (Crocus sativus)
    Purification, characterization and metabolomic investigation of flavonoid and other phenoloid natural products of Tilia spp.
    Metabolite variability and potential applications of Nostoc spp. (University of Debrecen, university grant)


Six significant publications


Deli J, Gonda S, Nagy L ZS, Szabó I, Gulyás-Fekete G, Agócs A, Marton K, Vasas G
Carotenoid Composition of three Bloom-forming Algae Species
FOOD RESEARCH INTERNATIONAL 2014: Paper FOODRES-D-14-00565R1. (2014)
IF: 3.050*

Gonda S, Kiss-Szikszai A, Szűcs Zs, Máthé Cs, Vasas G
Effects of N source concentration and NH4+/NO3- ratio on phenylethanoid glycoside pattern in tissue cultures of Plantago lanceolata L.: a metabolomics driven full-factorial experiment with LC-ESI-MS3
PHYTOCHEMISTRY 2014: Paper 10.1016/j.phytochem.2014.07.002. (2014)
IF: 3.350*

Gonda S, Kiss A, Emri T, Batta Gy, Vasas G
Filamentous fungi from Plantago lanceolata L. leaves: Contribution to the pattern and stability of bioactive metabolites
PHYTOCHEMISTRY 86: pp. 127-136. (2013)
IF: 3.350

Vasas G, Farkas O, Borics G, Felföldi T, Sramkó G, Batta G, Bácsi I, Gonda S
Appearance of Planktothrix rubescens Bloom with [D-Asp3, Mdha7]MC–RR in Gravel Pit Pond of a Shallow Lake-Dominated Area
TOXINS (BASEL) 5:(12) pp. 2434-2455. (2013)
IF: 2.480

Vasas G, M-Hamvas M, Borics G, Gonda S, Máthé Cs, Nagy ZsL
Occurrence of a toxic Prymnesium parvum bloom with high protease activity is related to fish mortality in Hungarian ponds
HARMFUL ALGAE 17: pp. 102-110. (2012)
IF: 2.901

Vasas G, Gáspár A, Páger Cs, Surányi Gy, M-Hamvas M, Máthé Cs, Borbély Gy
Analysis of cyanobacterial toxins (anatoxin-a, cylindrospermopsin, microcystin-LR) by capillary electrophoresis.
ELECTROPHORESIS 25:(1) pp. 108-115. (2004)
IF: 3.743